invivoid® - 3D Cell Culture Technology

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invivoid^® - An innovative tissue engineering technology that will achieve breakthrough in the next-generation drug discovery

"invivoid^®", an innovative 3D cell culture technology, that TOPPAN Holdings Inc. has developed in collaboration with Prof. Matsusaki of Osaka University, enables co-culturing of various types of cells using our proprietary cell culture methods, while controlling the behavior of cells.
Among a wide range of potential applications including drug discovery and regenerative medicine, invivoid^® enables groundbreaking in vitro 3D cancer / stromal models that achieve both reproduction of tumor microenvironment and high testing throughput.

Applications in: Oncology Research

Application in: Personalized Medicine

Applications in: Toxicology Research

Applications in: Regenerative Medicine (under construction)

　: invivoid^® Technology

Research Collaborations

Osaka University
- Prof. Michiya Matsusaki, Division of Applied Chemistry, Graduate School of Engineering
Japanese Foundation for Cancer Research
- Dr. Naoya Fujita, Center Director, Cancer Chemotherapy Center
- Dr. Ryohei Katayama, Chief, Division of Experimental Chemotherapy, Cancer Chemotherapy Center
- Dr. Kensei Yamaguchi, Deputy Hospital Director, Department Director of Gastroenterological Chemotherapy, Cancer Institute Hospital
- Dr. Eiji Shinozaki, Vice Director, Gastroenterological Chemotherapy Department, Cancer Institute Hospital

NEWS

2023/10/19

TOPICS

R&D on Social Implementation of Cultured Wagyu Beef Selected for Promotion Under NEDO’s Project for Development of Innovative Biomanufacturing Technologies

2023/05/11

TOPICS

JFCR, Osaka University, and Toppan Begin Clinical Research for Optimal Selection of Anticancer Drugs

2023/03/29

TOPICS

Osaka University, Shimadzu, Itoham Yonekyu, Toppan, and SIGMAXYZ have established “the future creation consortium for cultured meat.”

2022/04/25

TOPICS

Toppan and Myoridge to Collaborate on Products, Services, and R&D in the Field of Cell Culture

2022/04/14

TOPICS

Research Paper on Original Tissue Modeling Technology Using 3D Printing Named in Nature Communications 2021 Top 25 Life and Biological Sciences Articles

2021/08/27

NEWS RELEASE

Research Paper on Original Tissue Modeling Technology Using 3D Printing Featured in Nature Communications

2020/01/30

TOPICS

Promising Advances in Breast Regeneration Therapy

Publications

Posters
- Layered 3D co-cultured tumor model including vascularized stromal tissue may reflect drug sensitivities in vivo tumor(AACR2022)
- Construction of Hepatic Vascular Model and Toxicity Assessment System That Can Predict DILI Compounds(SOT2021)
- Unique layered 3D stromal tissue model for in vitro evaluating the behavior of immune cells in cancer microenvironment(JCA2021)
- Construction of Hepatic Vascular Model and Toxicity Assessment System That Can Predict DILI Compounds(SOT2020)
- A unique ex vivo tumor model: 3D co-cultured system with cancer and stromal cells including blood microvessels(ASCO-GI2020)
- A unique layered 3D stromal tissue model for in vitro evaluation of immunologic agents and immune cell infiltration into microenvironment(AACR2020)
- A unique ex vivo tumor model: 3D co-cultured system with cancer cells and stromal tissue for drug evaluation(AACR2020)
- A unique layered 3D stromal tissue model for in vitro evaluation of immunologic agents and immune cell infiltration into cancer microenvironment(AACR 2018)
- A unique ex vivo drug evaluation model: 3D co-cultured system with tumor, stroma and blood micro-vessels(AACR2018)
Peer-Reviewed Papers
- Naito Y et al., Acta Biomater. 2022 Mar 1;140:275-288. doi:10.1016/j.actbio.2021.11.027.
- Louis F et al., Adv Healthc Mater. 2022 Dec;11(23):e2201440. doi: 10.1002/adhm.202201440.
- Louis F et al., Bioact Mater. 2021 May 30;7:227-241. doi: 10.1016/j.bioactmat.2021.05.020.
- Kang DH et al., Nat Commun. 2021 Aug 24;12(1):5059. doi: 10.1038/s41467-021-25236-9.
- Hassan G et al., Processes 2021, 9(1), 45; https://doi.org/10.3390/pr9010045
- Louis F et al., Cyborg Bionic Syst. 2021 Mar 13;2021:1412542. doi:10.34133/2021/1412542.
- Nakatsuji H et al., Mater Horiz. 2021 Apr 1;8(4):1216-1221. doi: 10.1039/d0mh02058c.
- Yanagisawa K et al., Biology (Basel). 2020 Oct 27;9(11):361. doi:10.3390/biology9110361.
- Liu H et al., Adv Biosyst. 2020 May;4(5):e2000038. doi:10.1002/adbi.202000038.
- Nakatsuji H et al., Curr Protoc Cell Biol. 2020 Sep;88(1):e112. doi: 10.1002/cpcb.112.
- Li J et al., ACS Biomater Sci Eng. 2020 Oct 12;6(10):5711-5719. doi:10.1021/acsbiomaterials.0c00427.
- Naka Y et al., Mater Today Bio. 2020 Apr 28;6:100054. doi: 10.1016/j.mtbio.2020.100054.
- Louis F et al., Acta Biomater. 2019 Jan 15;84:194-207. doi:10.1016/j.actbio.2018.11.048.
- Takeuchi H et al., PLoS Pathog. 2019 Nov 7;15(11):e1008124. doi: 10.1371/journal.ppat.1008124.
- Nakatsuji H and Matsusaki M, ACS Biomater Sci Eng. 2019 Nov 11;5(11):5610-5614. doi:10.1021/acsbiomaterials.9b00090.

Posters can be downloaded via CONTACT page.

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