SCROLL
invivoid®は次世代のドラッグディスカバリーに貢献する革新的なティッシュエンジニアリングテクノロジーです
生体に近い人工組織を簡便に作成できるため、薬効や毒性試験を含む創薬研究や再生医療など、幅広い応用可能性が期待されています。
特にがん研究では、腫瘍微小環境の再現と高い試験スループットを両立する画期的ながん/間質共培養モデルを実現し、がん免疫療法を含む次世代のドラッグディスカバリーへの貢献に挑戦します。
Research Collaborations
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国立大学法人 大阪大学
- 松崎典弥 教授 (工学研究科 応用化学専攻)
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公益財団法人 がん研究会
- 藤田直也 がん化学療法センター 所長
- 片山量平 がん化学療法センター 基礎研究部 部長
- 山口研成 がん研究会有明病院 副院長、消化器化学療法科 部長
- 篠崎英司 がん研究会有明病院 消化器化学療法科 副部長
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Publications
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ポスター
- Development of anisotropic fibers by simultaneous spinning of cells and collagen using phase separationI(ISCCM2024)
- Construction of a 3D mammary gland model using collagen microfiber(WBC2024)
- Development of 3D stromal tissue model for in vitro evaluating the behavior of immune cells(The 83rd JCA, 2024)
- Development of a 3D layered co-culture model using primary cultures for drug sensitivity testing in personalized medicine(13th AACR-JCA Joint Conference, 2024)
- Development of A Unique Drug Sensitivity Test Using Primary Culture CRC Clinical Specimen and 3D Co-culture Model(The 8th JCA-AACR Special Joint Conference, 2024)
- Development of 3D stromal tissue model for in vitro evaluating the behavior of immune cells(The 1st International Symposium on Cancer Immunology and Immunotherapy, 2023)
- Drug screening by layered 3D co-cultured tumor model including vascularized stromal tissue(AACR2023)
- Construction of 3D mammary gland tissues that can be co-cultured with mature adipocytes(FASEB2023)
- Cancer cell character alteration cultured in a novel collagen microfiber with high dispersibility could be retained after the removal of scaffold(SFB2023)
- Layered 3D co-cultured tumor model including vascularized stromal tissue may reflect drug sensitivities in vivo tumor(AACR2022)
- Construction of Hepatic Vascular Model and Toxicity Assessment System That Can Predict DILI Compounds(Pacifichem2021)
- Construction of Hepatic Vascular Model and Toxicity Assessment System That Can Predict DILI Compounds(SOT2021)
- Unique layered 3D stromal tissue model for in vitro evaluating the behavior of immune cells in cancer microenvironment(JCA2021)
- Construction of Hepatic Vascular Model and Toxicity Assessment System That Can Predict DILI Compounds(SOT2020)
- A unique ex vivo tumor model: 3D co-cultured system with cancer and stromal cells including blood microvessels(ASCO-GI2020)
- A unique layered 3D stromal tissue model for in vitro evaluation of immunologic agents and immune cell infiltration into microenvironment(AACR2020)
- A unique ex vivo tumor model: 3D co-cultured system with cancer cells and stromal tissue for drug evaluation(AACR2020)
- Development of an in vitro Vascularized Gingival Tissue Models for P. gingivalis Infection(BEMS2019)
- A unique layered 3D stromal tissue model for in vitro evaluation of immunologic agents and immune cell infiltration into cancer microenvironment(AACR 2018)
- A unique ex vivo drug evaluation model: 3D co-cultured system with tumor, stroma and blood micro-vessels(AACR2018)
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査読付き論文
- Maruyama K. et al., NPJ Precis Oncol. 2025 Jan 6;9(1):4. doi: 10.1038/s41698-024-00793-6.
- Sato K. et al., biomedicines 2024 Oct 23 (22):2500 10.3390/biomedicines12112500
- Piantno, M et al,, Trends Biotechnol., 2024 Sep 43 (2) 364-382 doi: 10.1016/j.tibtech.2024.08.008
- Sasaki N. et al., Acta Biomater. 2024 Sep 1;185:161-172. doi:10.1016/j.actbio.2024.07.001.
- Shiraishi, A. et al., Biochem Biophys Res Commun. 2024 Sep 17:725:150255. doi: 10.1016/j.bbrc.2024.150255.
- Takahashi, Y., Morimura, R. et al., Acta Biomater. 2024 Jul 15:183:111-129. doi: 10.1016/j.actbio.2024.05.037.
- Yamada A., et al., Mater Today Bio. 2024 Jun 26 :101097 10.1016/j.mtbio.2024.101097
- Louis F et al., Mater Today Bio. 2023 Aug 21:100720 doi: 10.1016/j.mtbio.2023.100720
- Suezawa T. et al., Advanced Science, 2023 Mar 23 doi.org/10.1101/2023.03.21.533590
- Shang Y. et al., Bull. Chem. Soc. Jpn. 2022, 95, 1163–1168 | doi:10.1246/bcsj.20220108
- Naito Y et al., Acta Biomater. 2022 Mar 1;140:275-288. doi:10.1016/j.actbio.2021.11.027.
- Louis F et al., Adv Healthc Mater. 2022 Dec;11(23):e2201440. doi: 10.1002/adhm.202201440.
- Sasaki N. et al., Biomater Sci. 2021 Sep 28;9(19):6574-6583. doi: 10.1039/d1bm00831e.
- Louis F et al., Bioact Mater. 2021 May 30;7:227-241. doi: 10.1016/j.bioactmat.2021.05.020.
- Kang DH et al., Nat Commun. 2021 Aug 24;12(1):5059. doi: 10.1038/s41467-021-25236-9.
- Hassan G et al., Processes 2021, 9(1), 45; https://doi.org/10.3390/pr9010045
- Louis F et al., Cyborg Bionic Syst. 2021 Mar 13;2021:1412542. doi:10.34133/2021/1412542.
- Nakatsuji H et al., Mater Horiz. 2021 Apr 1;8(4):1216-1221. doi: 10.1039/d0mh02058c.
- Louis F et al., Biochem Biophys Res Commun. 2020 Feb 17:S0006-291X(20)30286-2. doi:10.1016/j.bbrc.2020.02.020.
- Yanagisawa K et al., Biology (Basel). 2020 Oct 27;9(11):361. doi:10.3390/biology9110361.
- Liu H et al., Adv Biosyst. 2020 May;4(5):e2000038. doi:10.1002/adbi.202000038.
- Nakatsuji H et al., Curr Protoc Cell Biol. 2020 Sep;88(1):e112. doi: 10.1002/cpcb.112.
- Li J et al., ACS Biomater Sci Eng. 2020 Oct 12;6(10):5711-5719. doi:10.1021/acsbiomaterials.0c00427.
- Naka Y et al., Mater Today Bio. 2020 Apr 28;6:100054. doi: 10.1016/j.mtbio.2020.100054.
- Louis F et al., Acta Biomater. 2019 Jan 15;84:194-207. doi:10.1016/j.actbio.2018.11.048.
- Takeuchi H et al., PLoS Pathog. 2019 Nov 7;15(11):e1008124. doi: 10.1371/journal.ppat.1008124.
- Nakatsuji H and Matsusaki M, ACS Biomater Sci Eng. 2019 Nov 11;5(11):5610-5614. doi:10.1021/acsbiomaterials.9b00090.
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