Application in Regenerative Medicine
Towards the advancement of breast reconstruction
As part of basic research in the field of regenerative medicine, we are engaged in research on breast tissue construction.Conventional breast reconstruction following mastectomy has primarily involved silicone implants to prevent postoperative displacement and surrounding tissue fibrosis. However, in July 2019, sales of these implants were suspended due to suspected links to malignant lymphoma. Autologous tissue reconstruction, which involves harvesting and injecting the patient's own fat cells, is also performed. However, challenges remain with the engraftment rate, and further improvements are needed.
Initiative using invivoid®
Given this background, we are utilizing invivoid® to investigate the construction of mini-sized breast tissue with a vascular network. It is anticipated that the vascular network constructed by invivoid® will efficiently supply nutrients and oxygen to the transplanted cells, leading to a high engraftment rate. In fact, experiments using small animals have shown that mini-sized breast tissue created with invivoid® exhibits a significantly higher engraftment rate compared to conventionally harvested fat tissue.Building on this breast reconstruction research, we aim to explore the diverse potential of invivoid® and pursue its further application in regenerative medicine.
